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MIT professor at IIT Bombay lecture series
Mumbai
As
a part of the ongoing Golden Jubilee celebrationsdistinguish lecture series
at IIT Bombay, Professor Stephan J Lippard, Head of Department of Chemistry
from MIT University, delivered a public lecture on discovery, understanding
and invention of platinum anti-cancer drugs at PC Saxena Hall at IIT Bombay,
Powai.
Lippard's lecture focused on the history behind the discovery of the anticancer
activity of cis-diamminedichloroplatinum(II), the most potent anti-cancer drug
and a virtual cure for testicular cancer. Studies of the mechanism of the action
was described, together with synthetic efforts that have expanded the range
of tumours that can be successfully treated by the platinum drug family. The
various stages in the process, from serendipitous discover to understanding
to invention, was delineated. The lecture concluded with the presentation of
novel agents in which cancer-cell targeting units and cell-piercing carbon nano
tubes are tethered to platinum warheads for next generation anti-cancer drug
candidates.
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