Vendor News

Waters unveils advances in mass spectrometry and separations science

Waters Corporation recently unveiled several new mass spectrometry innovations at the 56th American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics, including the Waters XevoTM TQ MS System, an advanced tandem quadrupole mass spectrometer that allows scientists with varying levels of mass spectrometry (MS) expertise to quickly produce the highest quality data with confidence. In addition, Waters is previewing its new TRIZAIC UPLC System with nanoTile technology, a new UltraPerformance LC separations platform for both large and small molecule applications that will deliver information rich, high sensitivity analyses when coupled to Waters SYNAPT, High Definition MS (HDMS) and SYNAPT MS Systems. Other products announced include the VERIFYE High Definition Proteomics System, the nanoACQUITY UPLC System with 2D technology, and the Atmospheric Solids Analysis Probe (ASAP). "Mass spectrometry is a vital analytical tool for a wide variety of applications—pharmaceuticals, biotechnology, food safety, environmental," said Art Caputo, Executive Vice President and President, Waters Division. "Waters is meeting customers' needs by bringing to market technology that allows laboratories to be more efficient and productive and makes high-performance capabilities available to scientists in various disciplines."

The Xevo TQ MS System is an advanced tandem quadrupole mass spectrometer designed to deliver unrivalled performance and functionality. It uses innovative IntelliStart and ScanWave technologies to deliver versatility and advanced quantitative capability to a broader range of scientists. IntelliStart is new technology that simplifies instrument setup and time-intensive troubleshooting. It automatically ensures that the system is ready for use by performing mass calibration, setting MS resolution, generating compound specific MS methods (SIR or MRM) and optimising API source conditions for specific analytical conditions plus much more. The Xevo TQ MS System operating under MassLynx Software is equipped with a unique collision cell that can be operated in conventional T-Wave 1-enabled mode or in a new ScanWave-enabled mode. The ScanWave is an innovative use of T-Wave collision cell technology that improves duty cycle and significantly enhances the full scan capability to meet the demands of today's complex analyses. This allows scientists to more easily confirm the identities and structures of targeted analytes.

Also at ASMS, Waters is previewing its new TRIZAIC UPLC System with nanoTile technology. The first iteration of this innovation is the new TRIZAIC UPLC System with nanoTile technology designed to deliver exceptional sensitivity for limited-sample, direct-flow, nanoscale protein separations. For use with Waters SYNAPT HDMS and SYNAPT MS Systems, it combines novel microfluidic separation technology with Waters sub-two-micron column chemistries, unique solvent delivery and comprehensive data management for both large- and small-molecule applications. TRIZAIC represents a highly-intelligent, integrated systems approach to separation science-fueled by the company's unequalled UPLC technology.

Waters is augmenting its high definition proteomic strategy with the introduction of the new VERIFYE System solution for biomarker verification. VERIFYE delivers the fastest transition from global-discovery to targeted proteomics by expertly selecting proteotypic peptides for quantitative protein assays along with optimum Multiple Reaction Monitoring (MRM) parameters. It uniquely develops targeted UPLC/MS/MS methods by interrogating archived global-discovery data in contrast to commonly used in silico projections of proteotypic peptide suitability. The VERIFYE system solution is optimised for use with Waters TRIZAIC UPLC and Xevo TQ MS technologies. Xevo TQ MS features an enhanced production scan capability that allows highly-sensitive confirmatory MS/MS spectra of proteotypic peptides to be acquired concurrently with MRM data for unimpeachable protein quantification. The Waters VERIFYE system for hypothesis-driven proteomics completes Waters' high definition proteomics strategy-complementing the previously introduced global-discovery proteomics systems; IDENTITYE and EXPRESSIONE.